By Zaher A. Radi

The first thorough evaluation of cyclooxygenase inhibitors, together with their toxicity mechanisms and toxicopathological risks

Cyclooxygenases (COXs) are enzymes chargeable for the formation of a big category of organic mediators known as prostanoids. Prostanoids similar to prostaglandins mediate inflammatory and anaphylactic reactions. For these struggling with irritation and discomfort, the pharmacological inhibition of COXs, with non-steroidal anti inflammatory medicinal drugs (NSAIDs), reminiscent of ibuprofen, provides reduction. but using NSAIDs can set off toxicological results to boot, resulting in power overall healthiness risks.

Comparative Pathophysiology and Toxicology of Cyclooxygenases presents a accomplished review of the way COX inhibitors have an effect on a number of physically platforms, particularly the toxicity mechanisms brought on whilst the COX enzyme is inhibited. The e-book offers an creation to the invention of cyclooxygenases, their use as healing brokers, in addition to an old standpoint. laying off mild at the adjustments in expression, pathophysiology, and toxicology of COX inhibitors throughout species, the booklet deals a scientific exam of the results and pathophysiology of COX inhibitors and their mechanisms of toxicity, starting with the GI tract. next chapters cover:

  • The pathophysiology of COX inhibition on bone, tendon, and ligament healing
  • COX inhibitors and renal method pathophysiology and mechanisms of toxicity
  • The pathophysiologic function of COX inhibition within the ocular system
  • COX inhibition and the breathing and cardiovascular systems

The booklet additionally sheds mild at the newest examine dedicated to constructing COX inhibitors without hostile side-effects. the 1st e-book to supply an intensive comparative examine the toxicological results of COX inhibitors through the physique, this worthwhile source may also help develop the examine and improvement of more secure and greater COX drugs.

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