By Michael Bryant Smith

Although much less universal than α-amino acids, non-α-amino acids—where the amino team isn't at the carbon instantly adjoining to the carboxyl team yet is connected to a different carbon within the chain (for instance, the β, γ, δ carbon)—are parts of biologically very important molecules, are major within the pharmaceutical undefined, and are worthwhile beginning fabrics for plenty of components of natural chemistry. because the ebook of the 1st variation of this ebook approximately two decades in the past, man made paintings dedicated to the training of non- α-amino acids has increased greatly.

Methods of Non-α-Amino Acid Synthesis, moment Edition has been widely rewritten and reorganized, offering an up to date assessment of ideas and strategies for non-α-amino acid synthesis, fairly these amino acids which are key artificial intermediates or very important compounds of their personal correct. It makes a speciality of acyclic amino acids of C3–C10, but additionally aminoalkanoic carboxylic acids, aminoalkenoic acids, and aminoalkynoic acids. the hot version includes many up to date references and has a better emphasis at the organic significance of non-α-amino acids. as well as an array of man-made tools, the booklet deals discussions on why non-α-amino acids are important.

The ebook covers man made tools that depend on substituent refunctionalization, the conversion of cyclic precursors to acyclic amino acids, conjugate addition reactions, and enolate anion reactions and condensation reactions that result in non-α-amino acids. It additionally examines reactions and techniques that result in reliable diastereoselectivity and enantioselectivity in the course of synthesis. A bankruptcy dedicated to biologically vital amino acids comprises separate sections on GABA, GABOB, carnitine, DAVA, statine, and different major amino acids in addition to a brand new part on peptides and proteins that include non-α-amino acids. the ultimate bankruptcy addresses aminocyclic and heterocyclic amino acids.

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