By Francois Terrier
This publication presents a accomplished assessment of nucleophilic fragrant substitutions, targeting the mechanistic and artificial beneficial properties that govern those reactions.
The first bankruptcy offers an in depth mechanistic research of the standards deciding on the feasibility of SNAr substitutions, supplying decisive details to foretell regioselectivity of many reactions and to outline the stipulations for concerted SNAr tactics. Reflecting the foremost function performed by means of those species as intermediates in so much SNAr reactions, bankruptcy 2 then discusses the chemistry of anionic sigma-complexes. bankruptcy three describes the concept that of superelectrophilicity in SNAr substitutions, because it has lately emerged from the reactivity of strongly electron-deficient fragrant and heteroaromatic constructions. the various artificial purposes are thought of extensive within the chapters four and five that stick with on intermolecular and intramolecular nucleophilic fragrant substitutions. Then, bankruptcy 6 specializes in substitutions continuing officially via displacement of a hydride ion, a sizzling subject within the box. the ultimate bankruptcy brings jointly concise but entire discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions.
Authored via a hugely revered chemist who has contributed tremendously to the sphere during the last 20 years, this can be a useful details resource for all natural chemists operating in academia or the pharmaceutical and agrochemical industries.
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