By Leonidas Stefanis,J. N. Keller

there's expanding facts that hyperlinks jointly a variety of universal neurodegenerative illnesses, comparable to Parkinson’s and Alzheimer’s ailments. discovering universal subject matters within the pathophysiology of such problems is more and more vital. this article addresses any such universal theme—the proteasome. because the discovery of the proteasome a few twenty years in the past, major strides were made in our figuring out of proteasome biology and our figuring out of the function the proteasome performs in a wide selection of biochemical occasions. Taken jointly, those experiences have proven a massive position for the proteasome within the fields of phone biology, oncology, immunology, gerontology, and neuroscience. the focal point of this booklet is to supply a close research and provocative dialogue of what position general and aberrant proteasome functionality performs in regulating numerous features of mind homeostasis.

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